Research proposal: Improvement of ab initio gene annotation
msra(2003)
摘要
While genomes of many organisms were sequenced over the last few years, transform- ing the sequences into meaningful data remains a dicult task. The most important task in reading human genome is to identify genes, its structure and certain functional units, such as exonic and intronic structures, CDS, 3'UTR, 5'UTR, splicing patterns and other features. There was a significant progress made in the last 5 years, but many problems remain unaddressed, or quality of the best software available nowadays is still far from desirable. This document describes dierent approaches to build gene recognition soft- ware, discusses test runs information available, surveys literature and proposes further destination for the research aimed to Ph.D. degree in bioinformatics.
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关键词
functional unit,human genome
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