Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials.

Xianming Deng,Advait Nagle,Tao Wu,Tomoyo Sakata,Kerstin Henson,Zhong Chen,Kelli Kuhen,David Plouffe,Elizabeth Winzeler,Francisco Adrian,Tove Tuntland,Jonathan Chang,Susan Simerson,Steven Howard,Jared Ek,John Isbell,David C Tully,Arnab K Chatterjee,Nathanael S Gray

Bioorganic & Medicinal Chemistry Letters（2010）

引用 31|浏览73

暂无评分

摘要

A novel family of 1H-imidazol-2-yl-pyrimidine-4,6-diamines has been identified with potent activity against the erythrocyte-stage of Plasmodium falciparum (Pf), the most common causative agent of malaria. A systematic SAR study resulted in the identification of compound 40 which exhibits good potency against both wild-type and drug resistant parasites and exhibits good in vivo pharmacokinetic properties.

查看译文

关键词

1H-Imidazol-2-yl-pyrimidine-4,6-diamines,Antimalarial

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要