Evidence for correlation between the intensities of adjuvant effects and NOD2 activation by monomeric, dimeric and lipophylic derivatives of N-acetylglucosaminyl-N-acetylmuramyl peptides.

Adjuvanticity of a series of peptidoglycan fragments—known as muramyl peptides—and their lipophylic derivatives was examined and compared with the ability of these compounds to activate NF–kB pathway through NOD2.