Synthesis of a Biotin-Labeled Quorum-Sensing Molecule: Towards a General Method for Target Identification

Richard Spandl,Rebecca Nicholson,David Marsden,James Hodgkinson,Xianbin Su,Gemma Thomas,George Salmond,Martin Welch,David Spring

SYNLETT（2008）

引用 9|浏览5

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摘要

The synthesis of bacterial quorum-sensing regulator N-(3-oxohexanoyl)-L-homoserine lactone (OHHL) and biotin-tagged OHHL is reported. The latter will be applied to developing a general method to address the 'target identification problem' in chemical genetics.

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关键词

drugs,high-throughput screening,proteins,OHHL,quorum sensing

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