Synthesis of 9-fluorenemethyl boranophosphonodiphosphate via an H-phosphonate approach.

Hongyan Liu,Syed N Hashmi,Barbara Ramsay Shaw

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS（2007）

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摘要

9-Fluorenemethyl boranophosphonate 6 and its boranophosphonodiphosphate 7 were synthesized via an H-phosphonate approach. The method is efficient for the synthesis of acyclic compounds 6 & 7, and can be explored for the synthesis of nucleoside 5'-deoxy boranophosphonodiphosphate.

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关键词

boranophosphonate,boranophosphonodiphosphate,antiviral,H-phosphonate,triphosphate analogues

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