Pyrazolo[1,5-Alpha]Pyrimidines As Orally Available Inhibitors Of Cyclin-Dependent Kinase

Bioorganic & medicinal chemistry letters（2007）

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摘要

Properly substituted pyrazolo[1,5-a]pyrimidines are potent and selective CDK2 inhibitors. Compound 15j is orally available and showed efficacy in a mouse A2780 xenograft model. (C) 2007 Elsevier Ltd. All rights reserved.

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关键词

CDK2,kinase,inhibitors,pyrazolo[1,5-alpha]pyrimidine

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