Thiazole analogues of the NSAID indomethacin as selective COX-2 Inhibitors

Keith W. Woods,Richard W. McCroskey,Michael R. Michaelides,Carol K. Wada,Keren I. Hulkower,Randy L. Bell

Bioorganic & Medicinal Chemistry Letters（2001）

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摘要

The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.

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关键词

structure activity relationship,isoenzymes,membrane proteins

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