O-Arylmandelic acids as highly selective human PPAR α/γ agonists

Alan D Adams,Zao Hu,Derek von Langen,Adonis Dadiz,Alex Elbrecht,Karen L MacNaul,Joel P Berger,Gaochao Zhou,Thomas W Doebber,Roger Meurer,Michael J Forrest,David E Moller,A Brian Jones

Bioorganic & Medicinal Chemistry Letters（2003）

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摘要

A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARα-weighted agonists do not show the typical PPARγ associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay.

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