Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

We report the discovery of piperazine urea based compound 1, a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist. Compound 1 shows anti-obesity efficacy without potentiating erectile activity in the rodent models.

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关键词

Melanocortin subtype-4 receptor,MC4R,Partial agonist,Urea piperazine,Erectile dysfunction,Obesity

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