Design and synthesis of novel imidazoline derivatives with potent antihyperglycemic activity in a rat model of type 2 diabetes.

Louis Crane,Maria Anastassiadou,Salomé El Hage,Jean Luc Stigliani,Geneviève Baziard-Mouysset,Marc Payard,Jean Michel Leger,Jean-Guy Bizot-Espiard,Alain Ktorza,Daniel-Henri Caignard,Pierre Renard

Bioorganic & Medicinal Chemistry（2006）

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摘要

Two series of imidazolines derived of 2-(α-cyclohexyl-benzyl)-4,5-dihydro-1H-imidazole were synthesized and evaluated for their in vivo antidiabetic activity in a rat model of type-2 diabetes.

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关键词

Imidazoline,Imidazoline receptors,Type 2 diabetes mellitus,Glucose tolerance

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