Tetrahydro-4-quinolinamines identified as novel P2Y1 receptor antagonists

Ángel I. Morales-Ramos,John S. Mecom,Terry J. Kiesow,Todd L. Graybill,Gregory D. Brown,Nambi V. Aiyar,Elizabeth A. Davenport,Lorena A. Kallal,Beth A. Knapp-Reed,Peng Li,Allyn T. Londregan,Dwight M. Morrow,Shobha Senadhi,Reema K. Thalji,Steve Zhao,Cynthia L. Burns-Kurtis,Joseph P. Marino

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

High-throughput screening of the GSK compound collection against the P2Y1 receptor identified a novel series of tetrahydro-4-quinolinamine antagonists. Optimal substitution around the piperidine group was pivotal for ensuring activity. An exemplar analog from this series was shown to inhibit platelet aggregation.

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关键词

P2Y1 receptor,Antagonist,Platelet aggregation,Thrombosis,Tetrahydro-4-quinolinamine

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