Tumor necrosis factor alpha drives cadherin 11 expression in rheumatoid inflammation.

Bernard Vandooren,Tineke Cantaert, Mariëtte ter Borg,Troy Noordenbos,Rodger Kuhlman,Daniëlle Gerlag,Tim Bongartz,Kris Reedquist,Paul P Tak,Dominique Baeten

ARTHRITIS AND RHEUMATISM（2008）

引用 51|浏览12

暂无评分

摘要

Cadherin 11 expression is regulated by mediators of inflammation, such as TNFalpha. Since cadherin 11 plays an important role in cartilage destruction in experimental arthritis, down-modulation of cadherin 11 by potent antiinflammatory therapies in humans with arthritis may contribute to halting cartilage damage.

查看译文

关键词

adherens junctions,down regulation,nf kappa b,tumor necrosis factor

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要