N-Glycosyl-N'-[p-(isoamyloxy)phenyl]-thiourea Derivatives: Potential Anti-TB Therapeutic Agents

Thiocarlide (THC; N,N'-bis[p-(isoamyloxy)phenyl]-thiourea; also known as Isoxyl(R)) has been used in the past as an anti-tuberculosis agent. In an effort to improve the therapeutic value of THC, several N-glycosyl-N'-[p-(isoamyloxy)phenyl]-thiourea derivatives were synthesized by coupling an aniline derivative and glycosyl isothiocyanates. The minimum inhibitory concentration (MIC) values of the new products against M. tuberculosis were determined.