Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

Benjamin F Voight,Laura J Scott,Valgerdur Steinthorsdottir,Andrew P Morris,Christian Dina,Ryan P Welch,Eleftheria Zeggini,Cornelia Huth,Yurii S Aulchenko,Gudmar Thorleifsson,Laura J McCulloch,Teresa Ferreira,Harald Grallert,Najaf Amin,Guanming Wu,Cristen J Willer,Soumya Raychaudhuri,Steve A McCarroll,Claudia Langenberg,Oliver M Hofmann,Josée Dupuis,Lu Qi,Ayellet V Segrè,Mandy van Hoek,Pau Navarro,Kristin Ardlie,Beverley Balkau,Rafn Benediktsson,Amanda J Bennett,Roza Blagieva,Eric Boerwinkle,Lori L Bonnycastle,Kristina Bengtsson Boström,Bert Bravenboer,Suzannah Bumpstead,Noisël P Burtt,Guillaume Charpentier,Peter S Chines,Marilyn Cornelis,David J Couper,Gabe Crawford,Alex S F Doney,Katherine S Elliott,Amanda L Elliott,Michael R Erdos,Caroline S Fox,Christopher S Franklin,Martha Ganser,Christian Gieger,Niels Grarup,Todd Green,Simon Griffin,Christopher J Groves,Candace Guiducci,Samy Hadjadj,Neelam Hassanali,Christian Herder,Bo Isomaa,Anne U Jackson,Paul R V Johnson,Torben Jørgensen,Wen H L Kao,Norman Klopp,Augustine Kong,Peter Kraft,Johanna Kuusisto,Torsten Lauritzen,Man Li,Aloysius Lieverse,Cecilia M Lindgren,Valeriya Lyssenko,Michel Marre,Thomas Meitinger,Kristian Midthjell,Mario A Morken,Narisu Narisu,Peter Nilsson,Katharine R Owen,Felicity Payne,John R B Perry,Ann-Kristin Petersen,Carl Platou,Christine Proença,Inga Prokopenko,Wolfgang Rathmann,N William Rayner,Neil R Robertson,Ghislain Rocheleau,Michael Roden,Michael J Sampson,Richa Saxena,Beverley M Shields,Peter Shrader,Gunnar Sigurdsson,Thomas Sparsø,Klaus Strassburger,Heather M Stringham,Qi Sun,Amy J Swift,Barbara Thorand,Jean Tichet,Tiinamaija Tuomi,Rob M van Dam,Timon W van Haeften,Thijs van Herpt,Jana V van Vliet-Ostaptchouk,G Bragi Walters,Michael N Weedon,Cisca Wijmenga,Jacqueline Witteman,Richard N Bergman,Stephane Cauchi,Francis S Collins,Anna L Gloyn,Ulf Gyllensten,Torben Hansen,Winston A Hide,Graham A Hitman,Albert Hofman,David J Hunter,Kristian Hveem,Markku Laakso,Karen L Mohlke,Andrew D Morris,Colin N A Palmer,Peter P Pramstaller,Igor Rudan,Eric Sijbrands,Lincoln D Stein,Jaakko Tuomilehto,Andre Uitterlinden,Mark Walker, Nicholas J Wareham,Richard M Watanabe,Gonçalo R Abecasis,Bernhard O Boehm,Harry Campbell,Mark J Daly,Andrew T Hattersley,Frank B Hu,James B Meigs,James S Pankow,Oluf Pedersen,H-Erich Wichmann,Inês Barroso,Jose C Florez,Timothy M Frayling,Leif Groop,Rob Sladek,Unnur Thorsteinsdottir,James F Wilson,Thomas Illig,Philippe Froguel,Cornelia M van Duijn,Kari Stefansson,David Altshuler,Michael Boehnke,Mark I McCarthy

NATURE GENETICS（2010）

引用 2151|浏览147

暂无评分

摘要

Mark McCarthy and colleagues identify twelve new risk loci for type 2 diabetes through a large-scale genome-wide association and replication study in individuals of European ancestry. The identified loci affect both beta-cell function and insulin action and are enriched for genes involved in cell cycle regulation.

查看译文

关键词

Gene regulation,Genetic predisposition to disease,Genome-wide association studies,Type 2 diabetes,Biomedicine,general,Human Genetics,Cancer Research,Agriculture,Gene Function,Animal Genetics and Genomics

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要