Cyclic Variations Of Sr 233377 (Win 33377) And Effects On Antitumor Activity.

Mark P. Wentland,Robert B. Perni,Jianhua I. Huang,Ronald G. Powles,Suzanne C. Aldous,Kristina M. Klingbeil,A. Danielle Peverly,Ronald G. Robinson,Thomas H. Corbett,Julie L. Jones,James B. Rake,Susan A. Coughlin

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1996）

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摘要

Novel derivatives of SR 233377 (1, WIN 33377) where a pyrazolo ring fusion has been incorporated at the 1- and 9-positions of the thioxanthone ring displayed outstanding in vivo efficacy against the murine solid tumor Pane 03 (T/C values of 0% with log cell kill greater than or equal to 2.0). No relationship between structure and Pane 03 activity was observed because all analogues studied were highly active. Copyright (C) 1996 Elsevier Science Ltd

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