Digestion-resistant whey peptides promote antioxidant effect on Caco-2 cells

Juliana Santos de Espindola,Milena Ferreira Taccóla,Vera Sônia Nunes da Silva,Lucilene Delazari dos Santos,Bruno Cesar Rossini,Bruna Cavecci Mendonça,Maria Teresa Bertoldo Pacheco,Fabiana Galland

Food Research International（2023）

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摘要

•Whey static digestion produce high proteolysis, but resistant low MW peptides.•Peptides with high rate of hydrophobic amino acids but average surface hydrophobicity.•After digestion whey peptide promote antioxidant defense in enteric Caco-2 cell line.•Whey peptides inhibit ROS production and activates GSH and SOD pathways.•Val and Leu in the N-terminal region may be related with antioxidant activity.

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关键词

Whey hydrolysate,INFOGEST,Antioxidant peptides,Caco-2 cells,Antioxidant pathways

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