A Facile and Green Synthesis of a Naphthyridine Derivative: A Novel Hedgehog Pathway Modulator
SYNTHESIS-STUTTGART(2010)
摘要
A green and highly efficient synthesis of a naphthyridine derivative, a novel hedgehog pathway modulator, in high yield and purity from inexpensive starting materials is described. The key step involves an acid-promoted aryl amination reaction of aniline with naphthyridine halides.
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关键词
aryl amination,acid-promoted coupling,green chemistry,naphthyridine,pyridine cyclization
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