Synthesis and SAR studies of 3-phenoxypropyl piperidine analogues as ORL1 (NOP) receptor agonists.

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

A series of potent and soluble ORL1 agonists was prepared and evaluated. Compound 41 showed antinociceptive properties in mouse formalin paw test (ED50=1.07μmol/kg).

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关键词

ORL1,Nociception,Opioid,Analgesia

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