Endogenous cyclo-oxygenase substrates mediate the neuroactivity of evening primrose oil in rats

    Journal of Lipid Mediators and Cell Signalling, pp. 115-125, 1996.

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    Keywords:
    diabetes mellitusstreptozotocinaspirinneural transmissioncyclooxygenaseMore(7+)

    Abstract:

    The role of cyclo-oxygenase and or its substrate(s) on the neuroactivity of evening primrose oil was investigated on the basis that a blockade of cyclo-oxygenase activity using aspirin would inhibit neuroactivity of primrose oil if this effect was mediated by prostanoids. Streptozotocin diabetic rats and controls were all given large dose...More

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