DLB and PDD boundary issues

Abstract—For more than a decade, researchers have refined criteria for the diagnosis of dementia with Lewy bodies (DLB) and,at the same,time,have,recognized,that cognitive,impairment,and,dementia,occur,commonly,in patients,with Parkinson disease (PD). This article addresses the relationship between DLB, PD, and PD with dementia (PDD). The authors agreed to endorse “Lewy body disorders” as the umbrella term for PD, PDD, and DLB, to promote the continued practical use of these three clinical terms, and to encourage efforts at drug discovery that target the mechanisms of neurodegeneration,shared,by,these,disorders,of,-synuclein,metabolism.,We,concluded,that,the,differing,temporal sequence of symptoms and clinical features of PDD and DLB justify distinguishing these disorders. However, a single Lewy,body,disorder,model,was,deemed,more,useful,for studying,disease,pathogenesis,because,abnormal,neuronal