Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E₂17βG) Across the Blood-Brain Barrier

Daisuke Sugiyama,Hiroyuki Kusuhara,Yong-Joo Lee,Yuichi Sugiyama

Pharmaceutical Research（2003）

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摘要

Purpose.The purpose of present study is to investigate the involvement of multidrug resistance-associated protein 1 (Mrp1), Mrp2, and P-glycoprotein (Mdr1a) in the efflux transport of 17ß—estradiol-D-17ß-glucuronide (E217ßG) across the blood—brain barrier (BBB).

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关键词

blood-brain barrier,organic anion,efflux transport,mrp.

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Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E217βG) Across the Blood-Brain Barrier

Involvement of Multidrug Resistance Associated Protein 1 (Mrp1) in the Efflux Transport of 17β Estradiol-D-17β-Glucuronide (E₂17βG) Across the Blood-Brain Barrier