Rigidity Sensing at the Leading Edge through αvβ3 Integrins and RPTPα

    Biophysical Journal, pp. 1804-1809, 2006.

    Cited by: 216|Bibtex|Views2|Links
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    Keywords:
    cell line

    Abstract:

    Cells require optimal substrate stiffness for normal function and differentiation. The mechanisms for sensing matrix rigidity and durotaxis, however, are not clear. Here we showed that control, Shp2 −/− , integrin β 1 −/− , and talin1 −/− cell lines all spread to a threefold greater area on fibronectin (FN)-coated rigid polyacrylamide sur...More

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