CHEM3407 Medicinal chemistry (6 credits)

Aim / Fellow-up This course covers the chemical principles of drug design and drug action. Useful as an introduction to research in areas of bioorganic chemistry, bioinorganic chemistry, medicinal chemistry, pharmaceutical chemistry, and biotechnology. Contents Drug discovery, design, and development: lead discovery, pharmacophore, structure-activity relationships (SAR), computer-aided drug design, combinatorial chemistry and high-throughput drug screening. Drug-receptor interactions. Proteins and enzymes as drug targets. Metalloenzymes: structures and functions. Metals in medicine. DNA-Drug interactions. Drug metabolism. Prodrugs and drug delivery.