Subthreshold Sodium Currents and Pacemaking of Subthalamic Neurons

Neuron, pp. 109-120, 2003.

Cited by: 218|Views2


Neurons of the subthalamic nucleus (STN) are spontaneously active. By voltage clamping dissociated rat STN neurons with their own firing patterns, we found that pacemaking is driven by two kinds of subthreshold sodium current: a steady-state “persistent” sodium current and a dynamic “resurgent” sodium current, which promotes rapid firing ...More



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