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Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.

D Kim,L Wang,C G Caldwell,P Chen,P E Finke,B Oates,M MacCoss,S G Mills,L Malkowitz,S L Gould,J A DeMartino,M S Springer, D Hazuda,M Miller,J Kessler,R Danzeisen,G Carver,A Carella,K Holmes,J Lineberger,W A Schleif,E A Emini

Bioorganic & Medicinal Chemistry Letters（2010）

引用 71|浏览39
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摘要
A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor. The synthesis, SAR, and biological profiles of this class of antagonists are described.
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关键词
human ccr5 antagonists,hydantoins,hiv-1 infection
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