Sequential administration of 5-fluorouracil (5FU)/leucovorin (LV) followed by irinotecan (CPT-11) at relapse versus CPT-11 followed by 5-FU/LV in advanced colorectal carcinoma. A phase III randomized study.

Nicolas Tsavaris,Christos Kosmas,Helias Skopelitis,Nicitas Papadoniou,Aristidis Polyzos,George Zografos,Efstathios Adoniou,John Gryniatsos,Evangelos Felekouras,Michalis Zacharakis,Francheska Sigala, Christos Bacoyiannis,George Papastratis,Efstathios Papalambros

CHEMOTHERAPY（2007）

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摘要

Treating patients with CPT-11 upon progression to 5-FU/LV treatment seems to be superior to the opposite sequence. We used these treatments as sequential monotherapies (at progression/relapse), and the best results are gained when 5-FU/LV is followed by CPT-11 at disease progression or relapse.

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关键词

colorectal cancer, 5-fluorouracil, irinotecan, leucovorin

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