Cytotoxic Constituents From Bulbuphyllum Inconsipicum

Guishan Tan,Li Sun,Jianguo Cao,Xiumei Wang,Fushuang Li,KangPing Xu,YinHua Deng,Donglan Yan,Wei Zhang,YingJun Zhou,Yuanjian Li

Chinese Journal of Organic Chemistry（2006）

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摘要

A novel compound, 2-methoxy-3,4,7-trihydroxy-phenanthrene (1), along with 4-methoxy-2,5-dihydroxy-phenathrene (2), eugenitin (3) and 2,5-dihydroxy-4-methoxy-9,10-dihydroxyphenanthrene (4), was isolated from Bulbuphyllum inconsipicum. 1 and 2 suppressing HL-60 and SMMC-7721 cells were investigated in vitro with cytotoxic activity. Furthermore, synergistic inhibition of 1 and 2 with puerarin was assessed.

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关键词

Bulbuphyllum inconsipicum, 2-methoxy-3,4,7-trihydroxy-phenanthrene, cytotoxic activity, puerarin

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