Sequence variations in the public human genome data reflect a bottlenecked population history

Proceedings of the National Academy of Sciences of the United States of America, Volume 100, Issue 1, 2003, Pages 376-381.

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Keywords:
human genomelength scalegenome sequencesingle nucleotide polymorphismnucleotide diversityMore(1+)

Abstract:

Single-nucleotide polymorphisms (SNPs) constitute the great majority of variations in the human genome, and as heritable variable landmarks they are useful markers for disease mapping and resolving population structure. Redundant coverage in overlaps of large-insert genomic clones, sequenced as part of the Human Genome Project, comprises ...More

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