Serratiomycin, a new antibacterial peptolide from an eubacterium culture, MB 5691

A novel peptolide antibiotic, serratiomycin, 1, was isolated from the culture broth of a eubacterium by solvent extraction and column chromatography. The structure of 1 was determined to be cyclo(D-beta-hydroxydecanoyl-L-leucyl-L-seryl-L-allothreonyl-D-phenylalanyl-D-isoleucyl). 1 exhibited a weak and mostly Gram-positive antibacterial spectrum in vitro. (C) 1998 Elsevier Science Ltd. All rights reserved.