Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

CELL, pp. 847-857, 1989.

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transgenic mice

Abstract:

Three transgenic mouse lines designated Tg 69, 71, and 81 were produced harboring a Syrian hamster (Ha) prion protein (PrP) gene; all expressed the cellular HaPrP isoform in their brains. Inoculation of Tg 81 mice or hamsters with Ha prions caused scrapie in integral of 75 days; nontransgenic control mice failed to develop scrapie after g...More

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