Cytoskeletal association of the cholera toxin receptor in rat erythrocytes

Cholera toxin receptors are associated with the cytoskeletal residue of Triton X-100 extracts of rat erythrocytes. The solubilized cytoskeletal toxin-receptor complex appears to be a large macromolecular entity whose formation is facilitated by increased receptor occupancy. These findings suggest a role for GM 1 -gangliosides in transmembrane signalling and in the mechanism of action of cholera toxin.