Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要

Enzyme inhibitory activity of a series of non-nitrile dipeptides help to discern the nature of individual SAR contributions from P1 and P2 of dipeptide derived DPP4 inhibitors.

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关键词

DPP4,Serine protease,Diabetes,Non-nitrile,GLP-1

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