The synthesis and evaluation of [2.2.1]-bicycloazahydantoins as androgen receptor antagonists.

Aaron Balog,Mark E Salvati,Weifang Shan,Arvind Mathur,Leslie W Leith,Donna D Wei,Ricardo M Attar,Jieping Geng,Cheryl A Rizzo,Chihuei Wang,Stanley R Krystek,John S Tokarski,John T Hunt,Marco Gottardis,Roberto Weinmann

Bioorganic & Medicinal Chemistry Letters（2005）

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摘要

A novel series of [2.2.1]-bicycloazahydantoins has been designed and synthesized in an enantiospecific manner. Several of these compounds were found to act as antagonists to the androgen receptor.

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关键词

Androgen receptor,Hydantoin

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