Preventive administration of Mycobacterium tuberculosis 10-kDa heat shock protein (hsp10) suppresses adjuvant arthritis in Lewis rats.

Davide Agnello,Eugenio Scanziani,Giancamillo Mauro Di,Flavio Leoni,Daniela Modena,Paolo Mascagni,Martino Introna,Pietro Ghezzi,Pia Villa

International Immunopharmacology（2002）

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摘要

Adjuvant arthritis (AA) can be induced in Lewis rats by immunization with Mycobacterium tuberculosis (Mt) in oil. We have investigated the modulation of AA by mycobacterial 10-kDa heat shock protein (hsp10), administered according to several protocols known to induce immune tolerance and immune deviation.

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关键词

Adjuvant arthritis,Rheumatoid arthritis,Heat shock protein(s),Mycobacterium tuberculosis,Immune tolerance,Respiratory mucosa immunology

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