Mitotic activity of multinucleated giant cells with glial fibrillary acidic protein immunoreactivity in glioblastomas: an immunohistochemical double labeling study
Journal of Neuro-Oncology(2006)
摘要
Summary To investigate the mitotic activity of multinucleated giant cells (MNGCs) with glial fibrillary acidic protein (GFAP) in glioblastomas, double immunohistochemical staining for GFAP and Ki67 was performed in formalin-fixed and paraffin-embedded specimens obtained from 12 primary glioblastomas with MNGCs including three giant cell glioblastomas. The Ki67 labeling index (LI:%) of GFAP+ tumor cells ranged from 0 to 5.6 (2.5±1.7, mean±standard deviation). The Ki67 LI of GFAP− tumor cells ranged from 18.6 to 35.9 (24.7±6.6). The Ki67 LI of GFAP+ cells was significantly lower than that of GFAP− cells ( P <0.0001). The number of Ki67+ GFAP− MNGCs ranged from 0 to 23 (8.6±8.2). The number of Ki67− GFAP+ MNGCs ranged from 0 to 15 (6.2±5.1). There was no significant difference between them ( P =0.42). The Ki67 LI of GFAP+ MNGCs was 10.4±12.6. The Ki67 LI of GFAP− MNGCs was 45.9±29.9. The Ki67 LI of GFAP+ MNGCs was significantly lower than that of GFAP− MNGCs ( P <0.01). Our study suggested that MNGCs with mitotic capacity were not dominant and that GFAP+ MNGCs had little mitotic activity in glioblastomas. MNGCs identified in glioblastomas may develop via not only the proliferation of abnormal nuclei in a single tumor cell but also other processes.
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关键词
GFAP,glioblastoma,Ki67,multinucleated giant cell
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