Brachyury regulatory region active in embryonal carcinoma P19 cells.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY(1999)
摘要
Brachyury (T) is Involved in mesoderm induction during early mouse development. We analyzed the region regulating expression of T in embryonal carcinoma P19 cells, which differentiate into mesoderm derivatives in vitro. Transfection of plasmids encoding reporter genes under the control of the 5'-flanking region showed positive regulatory elements between -298 and -129 bp are responsible for driving T expression in mesodermal cells.
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关键词
Brachyury (T),embryonal carcinoma,gene expression,mesoderm
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