Linkage of prion protein and scrapie incubation time genes

Cell, pp. 503-511, 1986.

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linkage geneticsgeneticspolymorphism geneticsrestriction enzymeinbred strainMore(1+)

Abstract:

A single gene ( Prn-i ) that affects scrapie incubation period in mice has been identified. I LnJ mice have a very long incubation period after inoculation of scrapie prions (200–385 days) and NZW LacJ mice have a short one (113 ± 2.8 days). (NZW × I Ln )F1 hybrid mice had incubation times of 223 ± 2.8 days indicating longer incubation ti...More

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