Tacrine derivatives-acetylcholinesterase interaction: 1H NMR relaxation study.

Maurizio Delfini,Maria Enrica Di Cocco,Fabiana Piccioni,Fernando Porcelli,Anna Borioni,Andrea Rodomonte,Maria Rosaria Del Giudice

Bioorganic Chemistry（2007）

引用 8|浏览4

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摘要

Two tacrine-based acetylcholinesterase (AChE) inhibitors, 6-methoxytacrine (1a) and 9-heptylamino-6-methoxytacrine (1b), and their interaction with Electrophorus Electricus AChE were investigated through spin–lattice relaxation times NMR. The ligand/enzyme interaction constants were evaluated for both compounds by the analysis of motional parameters.

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关键词

Acetylcholinesterase from Electrophorus Electricus,Tacrine derivatives,1H NMR relaxation, interaction

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