Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin

Molecular and cellular biology, Volume 22, Issue 5, 2002, Pages 1412-1423.

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Keywords:
cell motilitysignal processingsh3 domainbinding sitecell growthMore(4+)

Abstract:

The adapter protein Crk contains an SH2 domain and two SH3 domains. Through binding of particular ligands to the SH2 domain and the N-terminal SH3 domain, Crk has been implicated in a number of signaling processes, including regulation of cell growth, cell motility, and apoptosis. We report here that the C-terminal SH3 domain, never shown...More

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