Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity

Bioorganic & Medicinal Chemistry Letters（2011）

引用 25|浏览39

暂无评分

摘要

We report the design, synthesis, and SAR of triazolobenzodiazepinone CCK1 receptor agonists. Compound 4a is a potent, selective CCK1 receptor agonist which reduces food intake in rodents with minimal systemic exposure.

查看译文

关键词

CCK,Cholecystokinin,CCK1R,Gut selective,Triazolobenzodiazepinone

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要