Identification of a receptor-binding region in the core segment of the human anaphylatoxin C5a.
JOURNAL OF MEDICINAL CHEMISTRY(1994)
摘要
In order to identify regions of C5a that contribute to receptor binding and functional activity of the anaphylatoxin, a series of peptides was synthesized in which core segments have been attached to C-terminal segments via native peptidic or disulfide bonds. It has been found that residues Arg(40) and Arg(46) in the loop-3 region of the core induce a 1000-fold increase in the affinity of the disordered C-terminal segment of C5a. The results obtained from this work lead to the conclusion that the loop-3 region is most likely the core binding site of C5a.
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关键词
receptor binding
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