Angiopoietin-1 and Its Receptor Tie-2 Participate in the Regulation of Capillary-like Tubule Formation and Survival of Endothelial Cells

MICROVASCULAR RESEARCH, pp. 224-237, 1999.

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Abstract:

Angiopoietin-1 (Ang-1) and its receptor Tie-2, a transmembrane tyrosine kinase uniquely expressed by endothelial cells, are shown by mil mutation studies to be essential to developmental angiogenesis. The phenotypic abnormalities in these knockout animals suggest that Tie-2 signaling is necessary for the maintenance and expansion of the p...More

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