Applying proteomics to signaling networks.
Current Opinion in Genetics & Development(2004)
摘要
The information from genome sequencing provides a new framework for a systems-wide understanding of protein networks and cellular function. Whereas microarray technologies provide information about global gene expression within cells, complementary proteomic strategies monitor expression of proteins and their posttranslational modifications. Improved technologies that have emerged for comprehensive and high-throughput protein analysis yield novel insights into cell regulation.
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关键词
2DE,ICAT,IMAC,MS,ORF,PTM,RNAi,TAP
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