Microrna Regulation Of Messenger-Like Noncoding Rnas: A Network Of Mutual Microrna Control
Trends in genetics : TIG(2008)
摘要
Metazoan microRNAs (miRNAs) are commonly encoded by primary mRNA-like characteristics (miRNAs). To investigate whether mIRNAs are subject to miRNA control, we compared the expression of mIRNAs to that of tissue-specific miRNAs. We show that, like mRNAs, the expression levels of predicted mIRNA targets are significantly reduced in tissues where a targeting miRNA is expressed. On the basis of these results, we describe a potential network for posttranscriptional miRNA-miRNA control.
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