Aminomethylpiperazines as selective urotensin antagonists

Mark A. Hilfiker,Daohua Zhang,Sarah E. Dowdell,Krista B. Goodman,John J. McAtee,Jason W. Dodson,Andrew Q. Viet,Gren Z. Wang,Clark A. Sehon,David J. Behm,Zining Wu,Luz H. Carballo,Stephen A. Douglas,Michael J. Neeb

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

Aminomethylpiperazines, reported previously as being κ-opioid receptor agonists, have been developed into selective, high affinity human urotensin-II antagonists.

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关键词

Urotensin,Piperazine,Kappa,Opioid,Hypertension,7-TM

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