FC05-03 Altered levels of neurotrophic factors in alzheimer's disease patients with a lifetimne history of depression

Conclusion In Alzheimer's disease, the presence of depression co-morbidity corresponds to decreases in neurotrophic factors beyond effects of age, education, and medical co-morbidities, suggesting that the previously described link between major depression and the neuropathological processes in Alzheimer's disease may be related to changes in neuronal survival mediated by neurotrophic factors. Funded by the National Institute on Aging (U01 AG016976 and NIA P01-AG05138) and NARSAD.