Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.

Sue Cramp,Hazel J Dyke,Christopher Higgs,David E Clark,Matthew Gill,Pascal Savy,Neil Jennings,Steve Price,Peter M Lockey,Dennis Norman,Soraya Porres,Francis Wilson,Alison Jones,Nigel Ramsden,Raffaella Mangano,Dan Leggate,Marie Andersson,Richard Hale

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

The hit-to-lead exploration of a series of novel, potent and selective series of histamine H4 receptor inverse agonists originating from a virtual screening approach is described.

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关键词

Hit-to-lead,Hiatamine H4

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