Lipophilic peptide inhibitors of ribonucleotide reductase enzyme of herpes simplex virus

Istvan Toth,Gladstone Thompson,Peter Ward

International Journal of Pharmaceutics（1994）

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摘要

Lipophilic modified peptides corresponding to the COOH terminus of subunit 2 of herpes simplex virus ribonucleotide reductase were synthesised and evaluated. Lipidic conjugation on the N-terminus greatly enhanced the peptide inhibitory activity.

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关键词

Lipidic amino acid,Lipidic peptide,Herpesvirus ribonucleotide reductase inhibition

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