Benzofuran-substituted urea derivatives as novel P2Y1 receptor antagonists

Reema K. Thalji,Nambi Aiyar,Elizabeth A. Davenport,Joseph A. Erhardt,Lorena A. Kallal,Dwight M. Morrow,Shobha Senadhi,Cynthia L. Burns-Kurtis,Joseph P. Marino

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Benzofuran-substituted urea analogs have been identified as novel P2Y1 receptor antagonists. Structure–activity relationship studies around the urea and the benzofuran moieties resulted in compounds having improved potency. Several analogs were shown to inhibit ADP-mediated platelet activation.

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关键词

P2Y1,Purinergic,Thrombosis,Antiplatelet,Urea

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