Discovery of GSK345931A: An EP1 receptor antagonist with efficacy in preclinical models of inflammatory pain

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

This paper details the discovery and characterization of GSK345931 (7i) from the lead compound 4.

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关键词

EP1 antagonist,Pain,Inflammatory pain,CNS penetration,Free concentration

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